85 ATRIAL FIBRILLATION INCIDENCE IN SARS-COV-2 INFECTED PATIENTS: PREDICTORS AND RELATIONSHIP WITH IN-HOSPITAL MORTALITY

Abstract Background Among the different CardioVascular (CV) manifestation of COronaVIrus-related Disease (COVID) particular attention has been paid to arrhythmia and particularly Atrial fibrillation (AF). The aim our study was assess incidence AF episodes in patients hospitalized for COVID evaluate its predictors relationship with in-hospital all-cause mortality. Methods We enrolled 3435 cases SARS-CoV2 infection admitted four hospitals Northern Italy. collected data on clinical history, vital signs, Intensive Care Unit (ICU) admission, laboratory tests pharmacological treatment. incident mortality were considered as outcomes. Results 145 (4.2%) develop during hospitalization, a median time 3 days (IQR: 0, 11.5) from admission. Incident older had lower eGFR, platelet lymphocytes count higher C-Reactive Protein (CRP), more frequently ICU died compared subjects that didn't present AF. At Cox regression model significant determinants age (HR 1.070; 95% CI: 1.048, 1.092), history 2.800; 1.465, 5.351), ischemic heart disease 0.324; 0.130, 0.811) admission 8.030; 4.511, 14.292). predictor 1.679; 1.170, 2.410), together 1.053; 1.042, 1.065), dementia 1.553; CI 1.151, 2.095), 0.997; 0.996, 0.999) CRP 1.004; 1.003, 1.005) eGFR (HR: 0.991; 0.986, 0.996) Conclusion main COVID-19 development hospitalization strongly relates